At least 49 people were killed and more than 600 people were injured when a train plowed into a platform at a Buenos Aires station today, state media said.

British Prime Minister David Cameron will hold talks at 10 Downing Street on Wednesday to discuss racism in football following several high profile incidents in the English Premier League.

Singing sensation Adele continued rolling in the prizes at the Brit Awards in London, but she made headlines Wednesday for something else: she gave the middle finger when she was cut off during the live broadcast.

Five people were killed in a suburban Atlanta spa Tuesday night in a shooting that police said appeared to be a murder-suicide.

An Indiana lawmaker who opposes celebrating the centennial anniversary of the Girl Scouts of America says the group "sexualizes" young girls, promotes homosexuality and is a tactical arm of Planned Parenthood.

Two days of talks with Iran failed to produce agreement on how to verify that Iran's nuclear program remains peaceful, the International Atomic Energy Agency said.

A poll released Wednesday showed Rick Santorum maintaining his lead nationwide among likely Republican voters, topping his closest rival Mitt Romney by a margin of nine percentage points.

Wednesday night's CNN debate lands at a critical moment in the Republican race, especially for Mitt Romney, says Timothy Stanley

The GOP presidential debate Wednesday is the last time the candidates will share a stage before primaries in Arizona and Michigan on Tuesday.

Violence left five people dead today as protests over Quran burning by coalition troops intensified in Afghanistan. The U.S. Embassy in Kabul went into lockdown.